Brain/Bio Medical Microsystems Lab


Neural Interface

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Flexible electrodes
In order to provide chronic applications that offer long-term stability and precise measurements, flexible materials, such as those based on various polymers, are increasingly being integrated into the fabrication of microtechnologies. Multi-electrode arrays, also known as microelectrode arrays (MEAs), are one such field where flexible substrates are becoming critical components.
Neural probes
Traditional silicon-based neural probes have been widely used as multi-functional neuro tools that can read single-neuron signals as well as deliver drugs and other stimulants directly into the brain. Multifunctional probes that can simultaneously deliver stimulants and monitor neural circuits offer a promising approach to investigating the complexities of the brain.
Bio chips
The integration of microfluidics with microfabrication techniques has led to the development of miniaturized systems capable of biochemical assays at low cost and high throughput.
Bi-directional interface
Integration of various neural stimulators such as LEDs (optogenetics) and micromachined ultrasound transducers (CMUTs) with microelectrodes allow for simultaneous neural recording and neuromodulation.
  • Blue transparent OLEDs with high stability and transmittance for modulating sleep disorders
    H. Chae, Y. Park, Y. Jo, Y. Jeon, H. J. Lee, S. Yoo, and K. C. Choi*
    Advanced Materials Interfaces, 2202443 (2023) [link]

  • Multimodal neural probes with small form factor based on dual-side fabrication
    M. K. Kim
    , J. C. Leong, Y. Jo, G. Kook, and H. J. Lee*
    Advanced Materials Technologies 8(2), 2200692 (2022) [link]

  • A PVT-robust AFE-embedded error-feedback noise-shaping SAR ADC with copper-based passive high-pass IIR filtering for direct neural recording
    K. Jeong, Y. Jung, Y. Jo, H. J. Lee, S. Ha, and M. Je*
    IEEE Transactions on Biomedical Circuits and Systems 16(4), 679-691 (2022) [link]

  • A wide-dynamic-range neural-recording IC with automatic-gain-controlled AFE and CT dynamic-zoom Δ∑ ADC for saturation-free closed-loop neural interfaces
    Y. Jung, S.-J. Kweon, H. Jeon, I. Choi, J. Koo, M. K. Kim, H. J. Lee, S. Ha, and M. Je*
    IEEE Journal of Solid State Circuits 57(10), 3071-3082 (2022) [link]

  • A multimodal neural-recording IC with reconfigurable analog front-ends for improved availability and usability for recording channels
    T. Lee, M. K. Kim, H. J. Lee, and M. Je*
    ​IEEE Transaction on Biomedical Circuits and Systems​ 16(2), 185-199 (2022) [link]

  • Multifunctional multi-shank neural probe for investigating and modulation long-range neural circuits in vivo
    H. Shin, Y. Son, U. Chae, J. Kim, N. Choi, H. J. Lee, J. Woo, Y. Cho, S. H. Yang, C. J. Lee, and I.-J. Cho*
    Nature Communications 10, 3777 (2019) [link]

  • Wafer-scale multilayer fabrication for silk fibroin microelectronics
    G. Kook
    , S. Jeong, M. K. Kim, S. Lee, I.-J. Cho*, and H. J. Lee*
    ACS Applied Materials & Interfaces 11(1), 115-124 (2019) [link]

  • Neural probes for chronic applications
    G. Kook,, S. W. Lee, H. C. Lee, I.-J. Cho, and H. J. Lee*
    Micromachines 7(10), 179 (2016) [link]

  • In vivo optical modulation of neural signals using monolithically integrated two-dimensional neural probe arrays
    Y. Son, H. J. Lee, J. Kim, N. Choi, C. J. Lee, E.-S. Yoon, E. Yoon, K. Wise, T. G. Kim, and I.-J. Cho*
    Scientific Reports 5, 15466 (2015) [link]

  • Neural probes with multi-drug delivery capability
    H. Shin, H. J. Lee, U. Chae, H. Kim, N. Choi, J. Woo, Y. Cho, C. J. Lee, E.-S. Yoon, and I.-J. Cho*
    ​Lap Chip​ 15(18), 3730-3737 (2015) [link]

  • A new thin silicon microneedle with an embedded microchannel for deep brain drug infusion
    H. J. Lee, Y. Son, D. Kim, Y. K. Kim, N. Choi, E.-S. Yoon, and I.-J. Cho*
    ​Sensors and Actuators B:Chemical​ 209, 413-422 (2015) [link]